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Lifestyle - Caffeine Metabolism - Considerations

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The CYP1A2 gene variant that results in slower caffeine metabolism is CYP1A2*1F , whereas the CYP1A2*1A allele results in more efficient caffeine metabolism.  After you test with Genomic Express, you will know the genotype of both your CYP1A2 genes:  *1A/*1A (non-carrier),  *1A/*1F (heterozygous) or *1F/*1F (homozygous).  Non-carriers are the fastest metabolizers of caffeine, and moderate caffeine consumption in these individuals does not appear to significantly increase health risks.  Individuals with one or two *1F alleles are slow metabolizers of caffeine. This means that ingested caffeine stays in their body for longer times.  Individuals who are either heterozygous or homozygous for the *1F allele (which accounts for almost 50% of the general population) are slow caffeine metabolizers, and may benefit by modifying their caffeine consumption.

When you undergo genetic testing with Genomic Express, we will determine and report your CYP1A2 genotype.  You will learn whether you are a fast or slow metabolizer of caffeine.  Included in your comprehensive test report will be citations of the relevant scientific and medical research publications that report correlations between CYP1A2 genotype and health risks due to caffeine consumption.  This information may allow you to modify your caffeine intake in order to reduce your risk of future health problems.


Additional Information:


Cornelis, M.C., et al. (2006)  Coffee, CYP1A2 Genotype, and Risk of Myocardial Infarction. Journal of the American Medical Association 295 (10), 1135-1141.

Sata, F., et al. (2005)  Caffeine Intake, CYP1A2 Polymorphism and the Risk of Recurrent Pregnancy Loss. Molecular Human Reproduction 11 (5), 357-360.

Palatini, I., et al.(2009)  CYP1A2 genotype modifies the association between coffee intake and the risk of hypertension. J. Hypertens. 27(8), 1594-1601.

            This genetic test is provided by Genomic Express, Inc. for educational and informational purposes only. It is not intended for the diagnosis or treatment of any diseases or disorders. Clients should consult with their own physician or other qualified health care provider for any medical or health needs. Genomic Express, Inc. shall not be held liable for any damages incurred as a result of the use of this information or caused by products described herein. 

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